words : toxicity, human, rats, legistation;
The effects drugs accidental in childrens peoples odest. The carbon monoxide , cianet can there is in various soutain source; industrials how extraction of elements mina and your procucts, silver, erauser sintetic, inseticides, or naturals elements seed of pip, how plam, apricot; laetrile medicinal drug combat cancer, cherish, peachs, pear, the enzymes has a concentration of moleculs in the cells and when are metabolics some effects of drugs the main cause of the problem into nervous system (Alzheimer et. al. ) same patients and prenancyt into reitrenment hospitals comparative studys during treatment that concetrations the anestesic solutions cause by birth in childrens there is a develompement to coordinate motor, to face the consequences as result of that we understand to be studied induce by elemts toxics metals this cause encephalopathy, others effects cause, the cadmium ( Cd ) is a highty toxic element present en food and water. Soluble cadmium salts acumulate in organismus and result in pathological conditions to kidney . The effects of CdCl2 from differents routes of admistration were studied in this paper . Cadmium intake for seven days , from water solution ( 100mg/l ) induced incresead activities of CuZn superoxide dismutase ( Sod – e.c 188.8.131.52) in serum , and of total protein in urine on the other hand, cadmium by ip. Route , induce increased serum SOD and creatine. Lipoperoxide serum concetrations were decreased in these rats . No alterations were observed in total protein concetrations in rats treated by ip. Admistration . Since increased creatinine concentration in serum samples , is related to decreased glomerular filtration and kidney fails . Protein in urine is used as a n indicatior of leakly glomerulli, thus, increased proteinuria reflets renal cell damage, and significant damage to the glomerular membrane. The observation that lipoperoxide concentration decreased, while SOD activity was increased in rats with cadmium , indicated that renal lesions were related to free radicals . The Constituion of state Brazil search how know this alterations effects toxics elemnts cause a humam health with comparative the legislation, because very peoples are death a day in ours country.
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