words : toxicity, human, rats, legistation;   


   The effects drugs accidental in childrens peoples odest. The carbon monoxide , cianet can  there  is in various soutain source; industrials how   extraction of elements mina and your procucts, silver, erauser sintetic, inseticides, or naturals elements seed of pip, how plam, apricot; laetrile medicinal drug combat cancer,   cherish, peachs, pear,   the enzymes has a concentration  of moleculs in the cells    and when are  metabolics some effects of drugs the main cause of the problem into nervous  system (Alzheimer et. al. )  same patients and prenancyt into reitrenment hospitals  comparative studys during treatment that concetrations the anestesic solutions cause by birth in childrens   there is a develompement to coordinate motor, to face the consequences as result of that we understand to be studied  induce by elemts toxics metals this cause encephalopathy, others effects  cause,  the  cadmium  ( Cd )  is a  highty toxic element   present en food  and water. Soluble cadmium  salts acumulate  in organismus  and result  in pathological conditions  to kidney . The effects  of CdCl2  from differents  routes of admistration  were studied  in this paper . Cadmium intake  for seven days , from water solution ( 100mg/l ) induced  incresead activities  of CuZn superoxide dismutase ( Sod – e.c in serum , and  of total protein in urine  on  the other  hand, cadmium  by ip. Route , induce  increased serum SOD and creatine. Lipoperoxide serum concetrations  were  decreased in these rats . No alterations  were  observed  in total  protein  concetrations  in rats  treated  by ip. Admistration . Since  increased  creatinine  concentration  in serum samples , is related  to decreased glomerular filtration  and kidney fails . Protein  in urine  is used as a n indicatior  of leakly glomerulli, thus, increased proteinuria reflets renal cell damage, and significant  damage to the  glomerular membrane. The observation that lipoperoxide concentration decreased, while SOD activity was increased in rats with cadmium , indicated that renal lesions were related to free radicals . The Constituion of state Brazil  search how know this alterations effects toxics elemnts cause a humam health with comparative the legislation, because very peoples are death a day in ours country. 


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